For example, bisphenolA (BPA) can trigger intracellular signaling with activation of ERK1/2,independent from the expression of ERs in breast cancer cells.11 To add complexity to the evaluation of xenoestrogens,on the one hand, industrial chemicals are described to be detrimentalto the reproductive system,12,13 yet in contrast tothis, food-derived structural analogues to female sex hormones areappreciated for their health-promoting effects.14 Especially considering phytoestrogens, studies correlatinguse/exposure to breast cancer progression depict a complex picture.15−18. Here, MAPK3 is linked to breast cancer.