LGR5 and colorectal carcinoma: A functional screening of more than 500 BsAbs on CRC PDOs has been done by Herpers et al., from the screening they identified MCLA-158 BsAb targeting EGFRxLGR5 that target highly mitotic leucine-rich repeat-containing G-protein-coupled receptor 5-positive (LGR5+) CSC population supporting organoid growth found in primary and metastatic tumors.