NECTIN2 and pancreatic neoplasm: Immunofluorescence revealed that neutrophils expressing Nectin2 (Nectin2+ neutrophils) were more frequently observed in the TME of PDAC than in the adjacent normal pancreatic tissues (Fig. 4D–E). Additionally, TCGA analysis revealed considerably elevated Nectin2 expression in pancreatic tumors compared to normal pancreatic tissues (online supplemental Fig. 4G).