GZMA and Autoimmunity: We found that transcriptome of BRG1hiCD4+ cells was enriched in the synovial cytotoxic GNLYhiHOPXhi cells expressing IFNG, TNF and GZMA, and the peripheral T-helper cells abundant in the immune check-point receptors PD1/PDCD1, CTLA4, and LAG3 (Fig. 5C) and TNF-superfamily receptors OX40/TNFRSF4, GITR/TNFRSF18, LAIR2, known for the ability to infiltrate inflamed tissue and to drive autoimmunity in RA [66–68].