Through the peptide binding array, compositional analysis, and structural modelling of the docking, we predict the anchoring interaction between survivin and the BRG1/SWI complex subunits and propose their concerted action in mediating IFNγ effects on DNA damage response, further confirming the relevance of this action in autoimmune CD4+ cells of patients with rheumatoid arthritis. Here, SMARCA4 is linked to rheumatoid arthritis.