Liquid phase separation (LLPS)- or liquid condensates-dependent kinase activation has recently been widely reported, providing a new molecular mechanism model for protein kinase activation and substrate phosphorylation in the cytoplasm, which contributes to particular disease development, such as LLPS accelerated Tau protein phosphorylation in Alzheimer’s disease, and liquid condensates drove kinase fusion activation in cancer cells (López-Palacios et al, 2023; Sang et al, 2022; Tulpule et al, 2021; Sampson et al, 2021). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.