CTNNB1 and neoplasm: Indeed, whereas Harada et al. demonstrated in 2002 that the expression of ∆exon3 CTNNB1 in mouse hepatocytes was not sufficient for hepatocarcinogenesis [34], Colnot et al. demonstrated that the deletion of APC in the liver allows the formation of activating ß-catenin mediated tumours in mice [17].