SMDT1 and cancer: Compared to known components of MCUC such as MCU, EMRE, MICU1, MICU2, and MCUB, EFHD1 showed great variability in gene expression across 1450 cancer cell lines from 29 different lineages (Fig. EV5A) but was consistently upregulated in breast, uterine, ovarian, and cervical cancer cells, both at the RNA and protein (Fig. EV5B) level.