DCLK1 and enterovirus infectious disease: In this study, we established EV71 infection model in C57BL/6J and IL-25−/− mice and recognized tuft cells by its specific biomarkers TRPM5 (transient receptor potential melastatin five channel) and DCLK1 (doublecortin-like kinase 1) to investigate the training capacity of IL-25 on tuft cells in intestinal tissues and tried to explain the immune training mechanism of the different susceptibility in enteroviral infections between adults and children.