To explore the epigenetic alterations underlying the changes in HNF4α chromatin binding during sepsis, we analyzed the liver 8 h after sham or CLP with ‘Assay for transposase-accessible chromatin using sequencing’ (ATAC-Seq), as well as ChIP-Seq for H3K4me3 and H3K27ac (Fig. 3A). Here, HNF4A is linked to Sepsis.