HNF4A and Cirrhosis: Hepatic HNF4α is downregulated in NAFLD (Xu et al, 2015, 2021) and in advanced cirrhosis (Florentino et al, 2020) at the expression level, transcribed from an alternative promoter (P2 promoter) (Argemi et al, 2019) in AH, and accumulates in the cytoplasm due to reduced acetylation in advanced cirrhosis (Florentino et al, 2020).