HNF4A and Sepsis: On the other hand, genes upregulated in Hnf4aflfl by CLP as well as in Hnf4aLiver-i-KO relative to Hnf4aflfl in sham may be regarded as components of toxic pathways that become more active during sepsis due to the HNF4α LOF (Fig. 4E right panel; Dataset EV1).