Recently, SF3B1 mutations in uveal melanoma (UVM), myelodysplastic syndrome (MDS), and CLL were associated with mis-splicing of Bromodomain Containing 9 (BRD9), a subunit of the non-canonical BRG1 (SMARCA4) or BRM (SMARCA2) associated factor (ncBAF) chromatin remodeling complex [18]. Here, SMARCA2 is linked to B-cell chronic lymphocytic leukemia.