In a similar comparison of RNA-seq data from ICGC CLLE-ES [30, 31] (Supplementary Fig. 10A, B) and TCGA CLL [29, 33, 34] (Supplementary Fig. 10C–E), we observed an overlap between the 3 datasets, indicating upregulation of ZBTB48 and TAS1R1 in SF3B1MUT (Fig. 5D). Here, TAS1R1 is linked to B-cell chronic lymphocytic leukemia.