Recently, SF3B1 mutations in uveal melanoma (UVM), myelodysplastic syndrome (MDS), and CLL were associated with mis-splicing of Bromodomain Containing 9 (BRD9), a subunit of the non-canonical BRG1 (SMARCA4) or BRM (SMARCA2) associated factor (ncBAF) chromatin remodeling complex [18]. The gene discussed is SF3B1; the disease is B-cell chronic lymphocytic leukemia.