To determine if CBFβ presents a tumour cell vulnerability specific to CAR-T cells, or is more broadly involved in the regulation of CD8+ T cell evasion, we next compared the enriched sgRNA from our CAR-T cell screen with the enriched sgRNA from our previously published OT-I T cell resistance screen in MC38-OVA cells [5] (Fig. 1H). This evidence concerns the gene CBFB and neoplasm.