In contrast, the two BD29 BA.1 markers each inversely correlated with Omicron COVID-19 in naive participants (Fig. 2a, b) [HR per 10-fold increase (95% CI): 0.31 (0.10, 0.96), P = 0.042 for BA.1 nAbs and 0.16 (0.03, 0.79), P = 0.024 for Spike IgG-BA.1 bAbs; both family-wise error rate adjusted (FWER) P = 0.118] (Fig. 2e). Here, CFB is linked to COVID-19.