BD1 antibody, measured at a median of 11 months post second dose, was poorly correlated with BD29 antibody and generally did not correlate with Omicron COVID-19 In comparison, Hertz et al. measured baseline IgG a median of 6 months from third to fourth Pfizer mRNA vaccine dose and showed individuals with low baseline IgG to index-strain receptor binding domain or index-strain S2 had significantly higher risk of COVID-19 during the Omicron wave of early/mid 202229. Here, DEFB1 is linked to COVID-19.