Our study validates the previously proposed [6] prognostic potential of a high ADAM8, ADAM9 and ADAM15 GE in a newly sequenced patient cohort and investigates the thus far scarcely studied clinical and functional role of ADAM8, ADAM9 and ADAM15 in two MM patient cohorts (MMRF CoMMpass study cohort and our own validation cohort) and seven HMCL. The gene discussed is ADAM15; the disease is Miyoshi myopathy.