GSEA comparing ADAM8/9/15high/low MM patient samples of two different cohorts or HMCL before and after ADAM8/9/15 siRNA knockdown revealed an upregulation of gene sets associated with proliferation and cell cycle/growth in the ADAM8/9/15high groups, with “G2/M checkpoint”, “E2F targets”, “MYC targets” and “MTORC1 signaling” among the most frequently upregulated gene sets. Here, ADAM8 is linked to Miyoshi myopathy.