IL-2/S4B6 injection from day 1 to day 3 post-infection potentiated IL-2Rα expression, ERK and AKT activation, and S6 phosphorylation in both OT-I WT and OT-I Mrtfab−/− cells at day 4, and restored activation and proliferation of OT-I Mrtfab−/− cells to levels comparable to wildtype (Fig. 6B). Here, AKT1 is linked to infection.