To identify the relevant integrin α-subunit interacting with integrin β1 upon FXII-uPAR stimulation in DKD, we focused on integrins α6 and α5, which were the most downregulated alpha subunits (highest FDR values next to integrin β1) in hyperglycemic F12-/- mice kidneys compared to WT mice (Fig. 8a). Here, PLAUR is linked to diabetic kidney disease.