Furthermore, transcriptomic analysis of the Nephroseq® and the Karokidney public databases revealed that in addition to KNG1 (Supplementary Fig. S11a, b), the expression of the contact pathway genes KLKB1 (encoding kallikrein) and F11 (encoding FXI) were downregulated in DKD patients (Supplementary Fig. S15a, b). Here, KLK4 is linked to diabetic kidney disease.