Furthermore, transcriptomic analysis of the Nephroseq® and the Karokidney public databases revealed that in addition to KNG1 (Supplementary Fig. S11a, b), the expression of the contact pathway genes KLKB1 (encoding kallikrein) and F11 (encoding FXI) were downregulated in DKD patients (Supplementary Fig. S15a, b). This evidence concerns the gene KNG1 and diabetic kidney disease.