APOE and hyperlipidemia: To compare the effects of liver-targeted Angptl3 and Angptl4 silencing alone and in combination on hyperlipidaemia, female APOE*3-Leiden.CETP mice were treated with saline, negative (scrambled) ASO, anti-Angptl3 ASO, anti-Angptl4 ASO, or anti-Angptl3 ASO + anti-Angptl4 ASO for a total duration of 2 weeks.