These effects related to cumulative TC and TG exposure throughout the study (Figure 5D and E), which correlated strongly with the average lesion area (Figure 5F and G), suggesting that the alleviation of atherosclerosis development by Angptl3 and Angptl4 silencing was driven by the reduction in hypocholesteraemia as well as hypertriglyceridaemia. Here, ANGPTL3 is linked to hypertriglyceridemia.