Catusse et al. reported that, in pre-B acute lymphocytic leukemia cells, the receptor GPR30 mediated the ability of CCL18 to suppress Ca2+ mobilization and chemotaxis responses to CXCL12, but this does not account for the induction of such responses in T cells by CCL18 [28]. The gene discussed is CXCL12; the disease is acute lymphoblastic leukemia.