Given MEF2C’s association with neuropsychiatric disorders and cognitive function, we sought to investigate if the direct targets of MEF2C that are dysregulated by different mutations in the different cellular models are enriched for genes containing SNPs associated with SCZ and cognitive function from GWAS, as well as enriched for genes harboring rare de novo mutations (DNMs) contributing to neurodevelopmental disorders. The gene discussed is MEF2C; the disease is neurodevelopmental disorder.