To assess the impact of rare variants within the MEF2C gene-sets on SCZ and other neurodevelopmental disorders where cognitive impairment is a major feature (ASD, ID and DD), we examined whether these gene-sets exhibited enrichment for Syn, Mis, and Lof DNMs in trio-based exome sequencing studies of these disorders [32–40]. The gene discussed is MEF2C; the disease is neurodevelopmental disorder.