We also showed HOXD12 gene body hypermethylation and elevated expression were independently prognostic of published biomarkers and standard histopathological features, and we used single-nucleus RNA and ATAC sequencing to show that HOXD12 activity was localized to neoplastic cells rather than cells of the tumor microenvironment and was particularly strong within cycling and OPC-like cells. The gene discussed is HOXD12; the disease is neoplasm.