Li et al. [222] showed that mesenchymal stem cells-derived extracellular vesicles (MSCs-EVs) carrying miR-378a-3p can inhibit the GATA2/AQP4/PPAR-α pathway, therefore decreasing LPS-induced apoptosis in M064 cells and preventing the development of IBD. This evidence concerns the gene PPARA and irritable bowel syndrome.