CDH13 and Familial prostate cancer: One review discusses several genes that are differentially methylated in breast cancer between AA and CA women, e.g., methylation of CDH13, which is associated with triple negative breast cancers.31–33 Another systematic review of genetic and epigenetic differences in prostate cancer between African American patients and European American patients discussed differential methylation of multiple different gene promoters associated with prostate cancer.34 However, the clinical utility of these promoters are not certain.