Anyway, the father-to-son transmission of del9p24.3 (and the consequent NOA with varicocele) which occurred in the family here described demonstrates that DMRT1 alterations allow a residual conservation of a number of spermatozoa potentially sufficient to obtain pregnancies, even without ART, and this could also be valid for other overlapping conditions caused by similar molecular mechanisms. Here, DMRT1 is linked to varicocele.