Also, under glucose deprivation glutathione S-transferase P1 (GSTP1) has been shown to S-glutathionylate G6PD in MCF7 cells, while this modification is reduced in the presence of lactic acidosis, supporting an increase in both G6PD activity and cell proliferation (Sun et al., 2023 ▸). Here, G6PD is linked to lactic acidosis.