G6PD and cancer: In cancer cells, phosphorylation of Thr406 and Thr466 by Polo-like kinase 1 in the regulating cell cycle has been shown to affect G6PD dimerization and activity (Ma et al., 2017 ▸), while protein kinase A inhibits G6PD by serine phosphorylation (Xu et al., 2005 ▸).