In the adjuvant IMT group, the most frequent severe AEs were diarrhea (2.4%, 95% CI [1.6%–3.4%]), increased alanine aminotransferase (ALT) (2%, 95% CI [1.3%–3%]), and adrenal insufficiency (1.9%, 95% CI [1.1%–3%]). Here, GPT is linked to Adrenal insufficiency.