The mechanism behind epilepsy development and IFN-γ’s ability to augment the permeability of the small bowel epithelial barriers and blood-brain is associated positively.[55] In addition, research has indicated that it may affect the proportion of microglia.[56] Studies have found that by targeting miR-29a-HMGB1, which regulates neuronal apoptosis and neuroinflammation and thereby IFN-γ release, temporal lobe epilepsy can be controlled.[57] IFN-γ can indicate that epilepsy is not healing correctly. Here, HMGB1 is linked to temporal lobe epilepsy.