postmortem studies and experimental models have detected eosinophils in CNS tissues, raising questions about their possible roles in neuroinflammatory responses and their contribution to the pathophysiology of schizophrenia.[11] Eosinophils release various factors, including ECP, major basic protein, and eosinophil-derived neurotoxin, which have cytotoxic effects and modulate immune responses.[11] These eosinophil-derived proteins may potentially influence neuroinflammation and neuronal function, contributing to the complex inflammatory milieu characteristic of schizophrenia. This evidence concerns the gene RNASE3 and schizophrenia.