Premature ovarian failure (POF) is a syndrome caused by genetic factors, immune factors, and other causes of reduced follicular pool reserve or follicular dysfunction in the ovary, the etiology of which is unclear.[1] Age <40, amenorrhea 6 months, and blood follicle-stimulating hormone (FSH) levels > 40 mIU/mL are the generally accepted diagnostic criteria for POF. The gene discussed is BRD2; the disease is premature menopause.