The pooled analysis of the included studies revealed that patients with higher preoperative CRP (SMD 0.43, 95% CI 0.19–0.67) or lower preoperative ALB levels (SMD ‐0.35, 95% CI ‐0.59 to ‐0.12) were more prone to develop delirium following TJA. The gene discussed is ALB; the disease is delirium.