HIF1A and delirium: POD patients have markedly more white blood cells, enhanced neutrophil percentage and neutrophil/lymphocyte ratio, and a reduced mean platelet volume.[51] In another research, increased inflammatory cytokines (IL-6, IL-8) levels were found to associate with delirium.[50] In a cell study of nonalcoholic fatty liver disease, HIF-1α silence increases IL-6 secretion and aggravates inflammation in liver cells.[52] HIF-1α, a hypoxia regulatory factor is prominent against acute inflammation of different diseases.