Contrary to SIX1 overexpression, SIX1 KO (knockout) in HepG2 liver cancer cells and SIX1 KD in MHCC97H and SMMC‐7721 liver cancer cells reduced mRNA expression of ACLY, ACC1, FASN, and SCD1, and protein expression of ACLY, FASN, and SCD1 (Figure 1B). Here, ACACA is linked to liver cancer.