Since KO of AIB1 or HBO1 attenuates the ability of SIX1 to promote DNL in cancer cells, SIX1 is necessary for the recruitment of AIB1 and HBO1 to lipogenic gene promoters, and DNL is important for tumor growth and metastasis, targeting SIX1 may make liver cancer therapy more effective than targeting AIB1 or HBO1. The gene discussed is KAT7; the disease is liver cancer.