Many studies have shown that SIX1 is overexpressed in various human cancers and its elevated expression is associated with poor clinical outcomes.[14, 15, 16] SIX1 has been demonstrated to play a key role in cell metabolism, including glycolysis and hepatic lipogenesis.[21, 22] However, upstream regulators of SIX1 in DNL are not clear. Here, SIX1 is linked to cancer.