Long noncoding RNAs (lncRNAs) play important roles in gene regulation.[31] LncRNAs are also involved in a variety of cellular biological functions, such as cell differentiation, glycolysis, and lipogenesis.[32, 33, 34, 35] To identify potential lncRNAs regulating SIX1 expression, we used TANRIC database (https://www.tanric.org/) and ENCORI database (http://starbase.sysu.edu.cn/) to screen lncRNAs which are positively correlated with SIX1 expression, are overexpressed, and predict poor prognosis in patients with hepatocellular carcinoma. This evidence concerns the gene SIX1 and hepatocellular carcinoma.