From modeling results, we also found that the previous combinations with TGF‐β, MEK inhibitor, and Rosiglitazone focused on generation of the A state, which failed to make all the stable states associated with tumors become unstable (Figure 3), while our results provide optimized drug combinations to promote CAC, by eliminating all the tumor associated states and only keep the stable A state (Figure 4E). Here, TGFB1 is linked to neoplasm.