Preclinical studies have demonstrated that Piezo1, integrin, and YAP inhibitors significantly suppress tumor growth and metastasis, and some of the small molecule PROTACs have been evaluated in clinical trials.[48, 49, 50] However, we acknowledged the limitations of our current findings and the need for additional research to fully elucidate the complex interactions between Piezo1, integrin β1, and YAP signaling. This evidence concerns the gene PIEZO1 and neoplasm.