In previous publications by our group, we showed that different CBD-rich Cannabis extracts, with equal amounts of CBD but varying concentrations of other minor compounds, led to diverse anticonvulsant effects in a mouse model of epilepsy (Berman et al., 2018), and selective antitumoral effects in Notch1-mutated in T-ALL (Besser et al., 2023), suggesting the potential therapeutic effects of other compounds in the extracts in addition to CBD. This evidence concerns the gene NOTCH1 and epilepsy.