Compared to those in the other treatment groups, the expression levels of four cytokines, namely, IL‐1β, IFN‐γ, IL‐6, and TNF‐α, were significantly lower in the anti‐CD41‐PLT‐VP16 group of humanized mice with HLH (Figure 3D, p < 0.05). This evidence concerns the gene IFNG and hemophagocytic syndrome.