The outcomes of multivariate analysis demonstrated that tumor size (P<0.001; OR=3.893, 95%CI: 1.947-7.785), bilobular invasion (P=0.007; OR, 4.207, 95%CI: 1.492-11.867), AFP (P=0.035; OR=2.757, 95%CI: 1.075-7.070), and APRI (P=0.007; OR=4.422, 95%CI: 1.504-13.000) were independent predictors for early TACE refractoriness (Table 4). Here, AFP is linked to neoplasm.