This study aimed to describe the humoral immune response by correlating IgA and IgG antibodies with NAbs titres following CoronaVac® immunisation and an mRNA (Comirnaty®) booster among HCWs, and to describe the cytokines and interleukins profile antibodies by comparing the response between HCWs CoronaVac vaccinated and COVID-19 infected patients. This evidence concerns the gene CD79A and COVID-19.