PA‐induced lipotoxicity has been reported to contribute to neuropathy in T2D[35] and neurodegenerative diseases.[36, 37] To more accurately simulate the pathological environment of obesity in humans to explore the regulation of WFS1 in obesity, we added 1 × 10−3m PA to the cerebral organoids at 50 d and measured the size of the cerebral organoids 5 d later. The gene discussed is WFS1; the disease is obesity due to melanocortin 4 receptor deficiency.