It has been reported that riluzole normalizes HFD‐induced hyperactivation of glutamatergic transmissions and depression‐like behavior in mice.[17] Interestingly, we showed that riluzole mitigates HFD‐induced obesity and associated depression with reduced food intake and elevated O2 consumption and CO2 production with significant inhibition of ZnT3 expression in HFD mice (Figures 6A–F and 5G, H). The gene discussed is SLC30A3; the disease is obesity due to melanocortin 4 receptor deficiency.