To reveal whether MBNL proteins have an impact on the microtranscriptome of skeletal muscles, we analyzed small RNA fractions isolated from skeletal muscles of mouse models with a deficiency of MBNL1 or MBNL2 as well as in HSA-LR, the DM1 mouse model with sequestration of all MBNLs. This evidence concerns the gene ALB and myotonic dystrophy type 1.