The significant portion of convergent changes in miRNA levels observed in the skeletal muscles of mice with MBNLs knockout and in the muscles of DM1 patients indicates that MBNL functional knockdown leaves an imprint on the DM1 microtranscriptome and, consequently, on the expression of hundreds of protein-coding genes (Figure 5A, F). Here, MBNL1 is linked to myotonic dystrophy type 1.