A unique genetic signature underlying PD populations has been noted, with a predominance of GBA1 N396T variants found in the Portuguese, W378G in the French Canadian, K198E in the Colombian, K(−27)R in the Nigerian, and F216L and K(−27)R in the South African PD population.16, 29, 30, 31, 32. Here, GBA1 is linked to Parkinson disease.