Altogether, we conclude that inhibition of the CLK/DYRK family by Cir and Lor, results in a decreased phosphorylation of SRSF9, likely yielding a disturbed splicing machinery and concomitantly in a decreased expression of ARFL and ARV7, which, among other signaling pathways, contributes to the inhibitors' effects on cellular proliferation of Enza‐sensitive and ‐resistant PC cell lines. This evidence concerns the gene DYRK1A and pachyonychia congenita.