CLK1 and pachyonychia congenita: Altogether, we conclude that inhibition of the CLK/DYRK family by Cir and Lor, results in a decreased phosphorylation of SRSF9, likely yielding a disturbed splicing machinery and concomitantly in a decreased expression of ARFL and ARV7, which, among other signaling pathways, contributes to the inhibitors' effects on cellular proliferation of Enza‐sensitive and ‐resistant PC cell lines.