GSTM1 and type 2 diabetes mellitus: Another retrospective study in Japan found that in patients with T2DM and biopsy-proven diabetic nephropathy, lower Hb levels were associated with renal events (requirement for dialysis or 50% decline in estimated glomerular filtration rate from baseline) and all-cause mortality, especially in patients with severe interstitial fibrosis and tubular atrophy [126].