Neuron-OPCs synapses are retained in glioma (Venkatesh et al., 2019), and neuronal activity drives glioma proliferation through a paracrine mediator, such as neuroligin-3 from neurons (Venkatesh et al., 2015; Mancusi and Monje, 2023). The gene discussed is NLGN3; the disease is glioma.