NOS3 and stage 5 chronic kidney disease: Other variants in NOS3 have shown a clear link with end-stage renal disease (ESRD) (Elsaid et al., 2021; Padhi et al., 2022), chronic kidney disease (CKD) (Gunawan et al., 2020), CKD progression (Medina et al., 2018) and diabetic kidney disease (DKD) (Chen et al., 2016; Roumeliotis et al., 2021).