Furthermore, we and others have previously demonstrated the importance of SLC22A2 in CKD, renal traits and function (Chambers et al., 2010; Köttgen et al., 2010; Pattaro et al., 2016; Cañadas-Garre et al., 2024), thus revealing one of the many potential biological connections between the etiologies of CVD and CKD. The gene discussed is SLC22A2; the disease is chronic kidney disease.