In particular, the NOS3-rs3918226T variant was associated with an increased risk of CVD, CAD, hypertension, and values of SBP and DBP and decreased serum levels of Chol and LDL, whereas the NOS3-rs891511A variant was associated with decreased SBP and DBP in the overall and/or non-diabetic cohorts (Supplementary Document 2). Here, NOS3 is linked to hypertensive disorder.