In line with this, other TOMM40 variant previously linked to Alzheimer’s disease (Nazarian et al., 2019) and cerebral amyloid deposition (Yan et al., 2021) is rs71352238, found consistently associated with LDL and Chol levels in all cohorts in our study, bringing more evidence to the link between TOMM40, serum lipids and development of Alzheimer’s disease. The gene discussed is TOMM40; the disease is early-onset autosomal dominant Alzheimer disease.