The study carried out on the MES showed normocytic and normochromic anemia (hemoglobin 11.5mg/dL), acute kidney injury (new-onset creatinine 2.3mg/dL, baseline creatinine 0.8mg/dL and urea 61mg/dL), hypercalcemia (ionized calcium 1.6mEq/L), and high SACE level (serum angiotensin-converting enzyme) of 157U/L. This evidence concerns the gene ACE and anemia (phenotype).