INS and metabolic disease: This may be attributed to probable etiologies such as alterations in hormonal regulation, decreased insulin sensitivity, and impaired pancreatic function, all of which are associated with aging. Furthermore, the presence of a higher burden of chronic health conditions such as hypertension, cardiovascular disease, and metabolic disorders in the elderly may end in dysglycemia in sepsis states, as compared to the young (particularly less than 40 years of age).