VWF and autoimmune disease: Alteration of laboratory parameters related to coagulation status represents one of the main negative prognostic factors regarding COVID-19: prolonged prothrombin time (PT) and APTT and increased serum D-dimer and fibrinogen values, factor VIII and Von Willebrand factor, which may be suggestive for increased thrombotic risk.8,9 However, our patients did not present specific laboratory marker alteration neither autoimmune disorder excepting for mild D-dimer level elevations that may be suggestive of an acute thrombotic state.