Negligible expression of TH2-associatedgenes was observed at all time points in both lymphoid and myeloid clusters (Fig. 6A, 6B andSupplementary Fig. 9) except for high expression of KLF4 in myeloid clusters.Additionally, there was a high expression of LAG3, an exhaustion marker, and CD38, animmune activation marker in CD8+ T cell cluster post SIV co-infection at wk 11and at end of cART + 3HP treatment at necropsy. Here, KLF4 is linked to coinfection.