DEFA1 and neoplasm: Interestingly, the specificity of all four antibodies for paneth-cell-specific DEFA5 was demonstrated by the absence of HNP-1, HNP-2, HNP-3, and HNP-4 immunoreactive cells in consecutive sections of tonsil tumor tissue (Fig. 7A–D, right images), confirming the specificity of antibodies to DEFA5 in immunohistochemistry analysis.