The therapeutic efficacy of PTH in enhancing bone formation in osteopenic conditions such as osteoporosis is well-documented, and the underlying mechanisms have been extensively studied[28, 30].Our findings suggest an additional mechanistic role in bone pain modification, particularly in degenerative spinal conditions as has been documented in animal models of osteoarthritis and LBP[36, 47]. The gene discussed is PTH; the disease is Low back pain.