However, there is growing evidence that T2DM can also occur in people with normal body mass index (BMI) that and that normal-weight patients with T2DM exhibit a higher propensity for pancreatic β-cell failure, as well as having lower waist circumference, waist-to-hip ratio, total and visceral fat levels, and fasting insulin, fasting C-peptide, and insulin resistance indices (HOMA2-IR) compared with obese T2DM (2, 3). The gene discussed is INS; the disease is type 2 diabetes mellitus.